CUSHING'S SYNDROME, IDENTIFICATION OF ACTH SOURCE BY SELECTIVE CATHETERIZATION AND ACTH AND β-LPH ASSAYS
نویسندگان
چکیده
منابع مشابه
[Ectopic ACTH syndrome].
Cushing症 候群 は慢性的なコルチゾール過剰症であ り,放 置すると脳血管障害,糖 尿病,感 染症などで死 亡する.し たがって,適 切な診断 と治療が重要である. 表1に 示すように,ACTH依 存性Cushing症 候群 に は脳下垂体のACTH産 生腫によるGushing病 と異所 性ACTH症 候群があ り,ACTH非 依存性Cushing 症候群 には副腎原発性病変,医 原性 によるCushing症 候群がある.中 で もGushing病 と異所性ACTH症 候 群の鑑別 は治療法の選択 と関連 して重要である.我 々 が経験 した異所性ACTH症 候群を紹介する. 【症例】64歳,女 性.1993年 頃か ら顔面,下 腿の浮 腫,し びれ感 と全身の疼痛(肩 甲部,胸 部,腰 背部) を自覚するようになったため某院に入院した.糖 尿病, 高血圧,骨 粗鬆症 と診断さ...
متن کاملEctopic ACTH syndrome.
Ectopic adrenocorticotropic secretion (EAS) is responsible for 12-17% of cases of Cushing's syndrome (CS) and covers a range of tumours, from undetectable benign lesions to widespread metastases. The syndrome is often associated with severe hypercortisolaemia, which aggravates the underlying condition. EAS requires a complete workup that includes the establishment of endogenous CS, diagnosis of...
متن کامل[Technical and functional aspects of catheterization of inferior petrosal sinuses in ACTH dependent Cushing's syndrome].
OBJECTIVE To describe and analyze technique for bilateral catheterization of inferior petrosal sinus in our service, discussing the difficulties and success rates found. SUBJECTS AND METHODS Fourteen patients with suspected Cushing's syndrome underwent bilateral inferior petrosal sinuses (IPS) catheterization between 2009 and 2012. The technique for catheterization and for hormone analysis we...
متن کاملPlasma ACTH and Cortisol Levels in Patients with Ectopic ACTH Syndrome Base CRH Metyrapone Dex Patient Age Sex Tumor ACTH
To differentiate between ectopic ACTH syndrome and Cushing's disease, gene expression of corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC), and glucocorticoid receptor was examined in 10 pituitary adenomas (Cushing's disease) and in 10 ectopic ACTH-producing tumors. CRH increased plasma ACTH levels in all patients with Cushing's disease and in five patients with ectopic ACTH syn...
متن کاملEctopic ACTH syndrome: clinicopathological correlations.
Ten out of 164 cases of bronchogenic carcinoma showed pathological evidence at necropsy of the ectopic ACTH syndrome. All occurred in association with oat-cell carcinoma, constituting 19% of that group. The pathological features consisted of adrenocortical hyperplasia confined to the zona fasciculata and Crooke's hyaline change in the pituitary. Immunoperoxidase stainable ACTH was detected in t...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1988
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198801000-00167